In a 24-month clinical trial, tofacitinib proved safe and effective in combination with methotrexate in adult patients with RA…
Predictors of RA Flare After Total Joint Arthroplasty
At the time of total joint arthroplasty, RA disease activity has been shown to better predict postoperative flare than medication management…
How Does Health Literacy Affect the Patient Global Assessment?
For RA patients, a low score on the patient global assessment of disease activity as measured by a visual analog scale (PGA-VAS) is necessary to confirm remission. However, limited patient health literacy combined with the complexity of the scale may result in discrepancies between the PGA-VAS and provider assessments of disease activity. New research examined the patient perspective on the PGA-VAS and its connections to health literacy and disease state…
Characterization of Autoreactive B Cells in Patients with SLE & RA
Antibody-secreting cells are important for the pathophysiology of SLE and RA, but researchers have been unable to determine how these cells are activated. A new technique is able to distinguish between naïve autoreactive B cells and established antibody secreting cells…
Chronic Opioid Use in Rheumatoid Arthritis: Prevalence & Predictors
Over the past decade, physicians, patients and policy makers have expressed increasing concern about the high frequency of opioids being prescribed and the association between opioid use and poor outcomes. Rates of opioid prescriptions in the general population rose considerably from the 1990s through 2010, with a plateau in the early 2010s. In 2015, 38%…
More Data for Treat to Target: Post-Hoc Analysis of Large RA Clinical Trials Supports Treat-to-Target Recommendations
A post-hoc analysis of data from two large clinical trials supports treat-to-target recommendations for patients with rheumatoid arthritis. The research found baseline disease activity was the strongest predictor of a patient’s insufficient response to initial therapy at six months…
Galectin-3 May Be a Biomarker for Cardiovascular Disease in RA
Galectin-3 may have potential as a biomarker for the early onset of cardiovascular disease in RA patients, potentially enabling early intervention and deferring the cardiovascular risks associated with RA…
MRI-Guided Therapy Offers No Improvement Over Conventional Treat to Target for RA
New research does not support the use of a magnetic resonance imaging (MRI)-guided strategy for treating RA patients. The study found that among RA patients in remission, an MRI-guided treat-to-target strategy compared with a conventional treat-to-target strategy did not result in improved disease activity remission rates or reduced radiographic progression…
Rheumatoid Arthritis Risk Lower Among Smokers Who Quit
(Reuters Health)—Adults who quit smoking decades ago may have a lower risk of rheumatoid arthritis (RA) than people who gave up cigarettes more recently, a U.S. study suggests. Smoking has long been linked to an increased risk of RA, and quitting can reduce this risk. But the new study offers fresh evidence that years of…
Upadacitinib at the FDA
Upadacitinib is an investigational, oral, small molecule JAK1-selective inhibitor, which recently completed phase 3 clinical trials for treating patients with moderate to severe rheumatoid arthritis (RA). In late 2018, AbbVie Inc. submitted a New Drug Application to the U.S. Food and Drug Administration, as well as a marketing authorization application to the European Medicines Agency,…
- « Previous Page
- 1
- …
- 9
- 10
- 11
- 12
- 13
- …
- 30
- Next Page »