Stimulation with both Kveim reagent and vimentin induces a specific pro-inflammatory cytokine secretion from sarcoidosis PBMCs. Further investigation may identify novel biomarkers to assist the diagnosis of sarcoidosis…
Diagnosis Can Be Elusive for Fever of Unknown Origin
Settling into room 501 at Maine Medical Center, Mrs. N was on her way to the bathroom when she felt it coming on. One moment she was okay; the next, her chest felt damp and cold, even as her face flushed and her temperature spiked. Her forehead glistened beads of warm sweat. She felt the…
2015 ACR/ARHP Annual Meeting: Unknowns Persist Around Sarcoidosis Etiology, Pathogenesis, Treatment
SAN FRANCISCO—The Kveim-Siltzbach skin test for a diagnosis of sarcoidosis was developed in 1941, then popularized in 1961. Since then, the knowledge base about the disease has not expanded much, said Kristin Highland, MD, who has dual appointments at Cleveland Clinic’s Respiratory Institute and Orthopedics and Rheumatology Institute. “We don’t know a whole lot more…
2014 ACR/ARHP Annual Meeting: Diagnosis, Management of Sarcoidosis in the Heart, Central Nervous System
Without reliable diagnostic tests or evidence-based treatment guidelines, patient symptoms critical to diagnosing disease
Inflammatory Origin of Fever Is Key to Diagnosis
Fever in rheumatology patients may present evidence of an inflammatory process
Is Shared Decision Making Possible in Rheumatology?
A rheumatologist voices skepticism that physicians, patients can arrive at mutually shared healthcare decisions
Case Study in Dermatology: Familial Sarcoidosis/Blau Syndrome
Test your diagnostic knowledge with this case of multiple erythematous, slightly hyperpigmented waxy papules coalescing into plaques without scale over both distal lower extremities
Fellow’s Forum Case Report: New Sarcoidosis Cases in Patients Treated with Tumor Necrosis Factor–Alpha Inhibitors
Two patients with psoriatic arthritis treated with TNF-alpha inhibitor therapy develop the multisystem disease
Dermatology Case Review
A 33-year-old woman presents with somewhat pruritic, nodular lesions worsening over the past three months in the site of a newly placed tattoo. The nodules are restricted to certain portions of the tattoo only.
Dermatology Case Answer
Figure 2: Hematoxylin and eosin stain from punch biopsy of lesional skin demonstrated sarcoidal granulomas, inflamed. Review the case… The correct answer is D) Sarcoidosis: This patient’s first presentation of sarcoidosis consisted of skin lesions that were sarcoidal granulomas localized to a single pigment color within her tattoo (note the red pigment areas only are affected)….