2015 ACR/ARHP Annual Meeting: RA Pathogenesis and Prevention

“I expect that the next generation of rheumatologists will experience dramatic changes in the way that RA is evaluated and treated, with an increasing focus on screening and prevention and the identification of novel therapeutic targets and strategies in the preclinical period,” said Dr. Holers. “Consider how cardiovascular disease prevention has evolved over the last 30 years, and expect the same in RA and other rheumatologic and autoimmune diseases.”

Mary Beth Nierengarten is a freelance medical journalist based in St. Paul, Minn.

References

1. Sokolove J, Bromber R, Deane KD, et al. Autoantibody epitope spreading in the pre-clinical phase predicts progression. PLoS ONE. 2012;7(5):335296.
2. Gan RW, Trouw LA, Shi J, et al. Anti-carbamylated protein antibodies are present prior to rheumatoid arthritis and are associated with its future diagnosis. J Rheumatol. 2015;42(12).
3. Kolfenbach JR, Deane KD, Derber LA, et al. A prospective approach to investigating the natural history of preclinical rheumatoid arthritis using first-degree relatives of probands with RA. Arthritis Rheum. 2009;61(12):1735–1742.
4. Bhatia SS, Majka DS, Kittelson JM, et al. Rheumatoid factor seropositivity is inversely associated with oral contraceptive use in women without rheumatoid arthritis. Ann Rheum Dis. 2007;66(2):267–269.
5. Feser M, Derber LA, Deane KD, et al. Plasma 25, OH vitamin D levels are not associated with rheumatoid arthritis-related autoantibodies in individuals at elevated risk for rheumatoid arthritis. J Rheumatol. 2009;36(5):943–946.
6. Gan RW, Deane KD, Zerbe GO, et al. Relationship between air pollution and positivity of ra-related autoantibodies in individuals without established RA: A report on SERA. Ann Rheum Dis. 2013;72(12).
7. Norris JM, Gan RW, Hughes-Austin JM, et al. Lack of association between preclinical markers for cardiovascular disease and rheumatoid arthritis-related autoimmunity in first-degree relatives without rheumatoid arthritis. American College of Rheumatology 2013 Meeting Abstract #116.
8. Gan RW, Young KA, Zerbe GO, et al. Lower omega-3 fatty acids are associated with the presence of anti-cycliccitrullinated peptide autoantibodies in a population at risk for future rheumatoid arthritis: A nested case-control study. rheumatology 2015 Sep 13. pii: kev266. [Epub ahead of print].
9. Gan RW, Demoruelle MK, Deane KD, et al. Omega-3 fatty acids are associated with a lower prevalence of autoantibody positivity in HLA-DR shared epitope positive subjects who are at increased risk for future RA. American College of Rheumatology 2013 Meeting Abstract #2021