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Case Report: Is It Castleman Disease, or Castleman-Like?

Philip Chu, MD, RhMSUS, Mithu Maheswaranathan, MD, Jadee L. Neff, MD, PhD, & Rebecca E. Sadun, MD, PhD  |  Issue: October 2021  |  

Jadee L Neff, MD, PhDJadee L Neff, MD, PhD, is an assistant professor of pathology who subspecializes in hematopathology and molecular genetic pathology at Duke University School of Medicine, Durham, N.C. She is interested in biomarker discovery and assay development for diagnosis and therapeutic management of hematologic malignancy and mimics.

Rebecca E. Sadun, MD, PhDRebecca E Sadun, MD, PhD, is an adult and pediatric rheumatologist at Duke University School of Medicine, Durham, N.C., with an interest in how cognitive errors impact diagnostic reasoning in rheumatology.

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Disclosures

Dr. Neff is a consultant for EUSA Pharma and a participant in the company’s Peer to Peer Speaker’s Bureau regarding the criteria for pathologic diagnosis of Castleman disease.

References

  1. Fajgenbaum DC, Uldrick TS, Bagg A, et al. International, evidence-based consensus diagnostic criteria for HHV-8-negative/idiopathic multicentric Castleman disease. Blood. 2017 Mar;129(12):1646–1657.
  2. Wang L, Chen H, Shi J, et al. Castleman disease mimicking systemic lupus erythematosus: A case report. Medicine. 2018 Sep;97(38):e12291.
  3. Demirkan FG, Doğan S, Kalyoncu Uçar A, et al. Systemic lupus erythematosus complicated with Castleman disease: A case-based review. Rheumatol Int. 2021 Feb;41(2):475–479.
  4. Xia J-Y, Chen X-Y, Xu F, Yang Y, Wang H-Y, Xue J. A case report of systemic lupus erythematosus combined with Castleman’s disease and literature review. Rheumatol Int. 2012 Jul;32(7):2189–2193.
  5. Rhee F van, Voorhees P, Dispenzieri A, et al. International, evidence-based consensus treatment guidelines for idiopathic multicentric Castleman disease. Blood. 2018 Nov;132(20):2115–2124.

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